| Difficult Run to Eau Claire (Wisconsin) | 833.31 mi (1,341.08 km) |
| Difficult Run to Echelon (New Jersey) | 141.59 mi (227.87 km) |
| Difficult Run to Eden (North Carolina) | 211.17 mi (339.85 km) |
| Difficult Run to Eden Prairie (Minnesota) | 922.96 mi (1,485.36 km) |
| Difficult Run to Edgewater (Florida) | 716.99 mi (1,153.88 km) |
| Difficult Run to Edgewater (New Jersey) | 222.77 mi (358.51 km) |
| Difficult Run to Edgewood (Maryland) | 66.68 mi (107.31 km) |
| Difficult Run to Edgewood (Washington) | 2,305.98 mi (3,711.12 km) |
| Difficult Run to Edina (Minnesota) | 919.47 mi (1,479.74 km) |
| Difficult Run to Edinburg (Texas) | 1,484.96 mi (2,389.81 km) |
| Difficult Run to Edmond (Oklahoma) | 1,123.19 mi (1,807.59 km) |
| Difficult Run to Edmonds (Washington) | 2,307.94 mi (3,714.27 km) |
| Difficult Run to Edwards (Colorado) | 1,559.76 mi (2,510.18 km) |
| Difficult Run to Edwardsville (Illinois) | 679.69 mi (1,093.86 km) |
| Difficult Run to Effingham (Illinois) | 601.31 mi (967.71 km) |
