| Difficult Run to East Rancho Dominguez (California) | 2,278.76 mi (3,667.31 km) |
| Difficult Run to East Renton Highlands (Washington) | 2,296.14 mi (3,695.28 km) |
| Difficult Run to East Ridge (Tennessee) | 511.72 mi (823.53 km) |
| Difficult Run to East Riverdale (Maryland) | 23.79 mi (38.29 km) |
| Difficult Run to East San Gabriel (California) | 2,267.15 mi (3,648.62 km) |
| Difficult Run to East St. Louis (Illinois) | 688.46 mi (1,107.97 km) |
| Difficult Run to East Wenatchee (Washington) | 2,211.98 mi (3,559.83 km) |
| Difficult Run to Eastern Goleta Valley (California) | 2,350.76 mi (3,783.18 km) |
| Difficult Run to Eastlake (Ohio) | 287.41 mi (462.54 km) |
| Difficult Run to Eastmont (Washington) | 2,299.85 mi (3,701.25 km) |
| Difficult Run to Easton (Maryland) | 69.27 mi (111.48 km) |
| Difficult Run to Easton (Pennsylvania) | 167.14 mi (268.98 km) |
| Difficult Run to Eastpointe (Michigan) | 382.86 mi (616.16 km) |
| Difficult Run to Eastvale (California) | 2,244.13 mi (3,611.58 km) |
| Difficult Run to Eatontown (New Jersey) | 199.79 mi (321.53 km) |
