| Difficult Run to East Lake-Orient Park (Florida) | 806.69 mi (1,298.25 km) |
| Difficult Run to East Lansing (Michigan) | 457.82 mi (736.80 km) |
| Difficult Run to East Los Angeles (California) | 2,273.98 mi (3,659.62 km) |
| Difficult Run to East Massapequa (New York) | 241.05 mi (387.93 km) |
| Difficult Run to East Meadow (New York) | 236.97 mi (381.37 km) |
| Difficult Run to East Milton (Florida) | 789.99 mi (1,271.37 km) |
| Difficult Run to East Moline (Illinois) | 710.70 mi (1,143.76 km) |
| Difficult Run to East Niles (California) | 2,283.26 mi (3,674.56 km) |
| Difficult Run to East Northport (New York) | 253.28 mi (407.61 km) |
| Difficult Run to East Orange (New Jersey) | 210.34 mi (338.51 km) |
| Difficult Run to East Palo Alto (California) | 2,409.74 mi (3,878.11 km) |
| Difficult Run to East Patchogue (New York) | 265.12 mi (426.67 km) |
| Difficult Run to East Peoria (Illinois) | 658.36 mi (1,059.53 km) |
| Difficult Run to East Point (Georgia) | 536.38 mi (863.22 km) |
| Difficult Run to East Providence (Rhode Island) | 373.73 mi (601.45 km) |
