| Difficult Run to Eagle (Idaho) | 2,034.03 mi (3,273.46 km) |
| Difficult Run to Eagle Mountain (Utah) | 1,836.01 mi (2,954.78 km) |
| Difficult Run to Eagle Pass (Texas) | 1,497.19 mi (2,409.49 km) |
| Difficult Run to Easley (South Carolina) | 404.02 mi (650.21 km) |
| Difficult Run to East Bakersfield (California) | 2,285.70 mi (3,678.48 km) |
| Difficult Run to East Bethel (Minnesota) | 924.53 mi (1,487.89 km) |
| Difficult Run to East Chicago (Indiana) | 565.15 mi (909.52 km) |
| Difficult Run to East Cleveland (Ohio) | 287.83 mi (463.22 km) |
| Difficult Run to East Glenville (New York) | 326.93 mi (526.14 km) |
| Difficult Run to East Grand Rapids (Michigan) | 513.55 mi (826.48 km) |
| Difficult Run to East Hemet (California) | 2,215.49 mi (3,565.49 km) |
| Difficult Run to East Highland Park (Virginia) | 91.55 mi (147.33 km) |
| Difficult Run to East Honolulu (Hawaii) | 4,805.67 mi (7,733.98 km) |
| Difficult Run to East Islip (New York) | 254.19 mi (409.08 km) |
| Difficult Run to East Lake (Florida) | 805.50 mi (1,296.32 km) |
