| Difficult Run to Dumas (Texas) | 1,363.50 mi (2,194.35 km) |
| Difficult Run to Dumont (New Jersey) | 226.99 mi (365.30 km) |
| Difficult Run to Duncan (Oklahoma) | 1,175.77 mi (1,892.22 km) |
| Difficult Run to Duncanville (Texas) | 1,175.88 mi (1,892.40 km) |
| Difficult Run to Dundalk (Maryland) | 52.36 mi (84.26 km) |
| Difficult Run to Dunedin (Florida) | 813.33 mi (1,308.93 km) |
| Difficult Run to Dunkirk (New York) | 268.21 mi (431.65 km) |
| Difficult Run to Dunmore (Pennsylvania) | 196.47 mi (316.18 km) |
| Difficult Run to Dunwoody (Georgia) | 516.80 mi (831.70 km) |
| Difficult Run to Durango (Colorado) | 1,656.50 mi (2,665.88 km) |
| Difficult Run to Durant (Oklahoma) | 1,109.00 mi (1,784.76 km) |
| Difficult Run to Durham (North Carolina) | 219.19 mi (352.75 km) |
| Difficult Run to Dyer (Indiana) | 565.07 mi (909.39 km) |
| Difficult Run to Dyersburg (Tennessee) | 687.94 mi (1,107.14 km) |
| Difficult Run to Eagan (Minnesota) | 908.64 mi (1,462.32 km) |
