| Difficult Run to Dixon (Illinois) | 669.51 mi (1,077.48 km) |
| Difficult Run to Dobbs Ferry (New York) | 234.90 mi (378.04 km) |
| Difficult Run to Doctor Phillips (Florida) | 760.36 mi (1,223.68 km) |
| Difficult Run to Dodge City (Kansas) | 1,228.12 mi (1,976.47 km) |
| Difficult Run to Dolton (Illinois) | 571.91 mi (920.40 km) |
| Difficult Run to Donna (Texas) | 1,487.99 mi (2,394.68 km) |
| Difficult Run to Dorado (Puerto Rico) | 1,560.40 mi (2,511.22 km) |
| Difficult Run to Doral (Florida) | 920.92 mi (1,482.08 km) |
| Difficult Run to Doraville (Georgia) | 516.74 mi (831.61 km) |
| Difficult Run to Dothan (Alabama) | 698.26 mi (1,123.74 km) |
| Difficult Run to Douglas (Arizona) | 1,881.32 mi (3,027.69 km) |
| Difficult Run to Douglas (Georgia) | 597.82 mi (962.09 km) |
| Difficult Run to Douglasville (Georgia) | 542.85 mi (873.64 km) |
| Difficult Run to Dover (Delaware) | 99.68 mi (160.41 km) |
| Difficult Run to Dover (New Hampshire) | 448.25 mi (721.38 km) |
