| Difficult Run to Delaware (Ohio) | 319.48 mi (514.15 km) |
| Difficult Run to Delhi (California) | 2,338.90 mi (3,764.10 km) |
| Difficult Run to Delray Beach (Florida) | 874.52 mi (1,407.41 km) |
| Difficult Run to Deltona (Florida) | 725.21 mi (1,167.11 km) |
| Difficult Run to Deming (New Mexico) | 1,760.01 mi (2,832.47 km) |
| Difficult Run to Denison (Texas) | 1,125.21 mi (1,810.85 km) |
| Difficult Run to Dent (Ohio) | 392.82 mi (632.18 km) |
| Difficult Run to Denton (Texas) | 1,170.40 mi (1,883.58 km) |
| Difficult Run to Dentsville (South Carolina) | 388.96 mi (625.96 km) |
| Difficult Run to Denver (Colorado) | 1,466.62 mi (2,360.30 km) |
| Difficult Run to Depew (New York) | 285.99 mi (460.25 km) |
| Difficult Run to Derby (Connecticut) | 280.71 mi (451.76 km) |
| Difficult Run to Derby (Kansas) | 1,082.34 mi (1,741.87 km) |
| Difficult Run to Des Moines (Iowa) | 876.01 mi (1,409.80 km) |
| Difficult Run to Des Moines (Washington) | 2,307.08 mi (3,712.88 km) |
