| Difficult Run to Dallas (Oregon) | 2,367.32 mi (3,809.83 km) |
| Difficult Run to Dallas (Texas) | 1,163.70 mi (1,872.80 km) |
| Difficult Run to Dalton (Georgia) | 508.94 mi (819.06 km) |
| Difficult Run to Daly City (California) | 2,422.98 mi (3,899.41 km) |
| Difficult Run to Damascus (Maryland) | 26.72 mi (43.01 km) |
| Difficult Run to Damascus (Oregon) | 2,321.71 mi (3,736.43 km) |
| Difficult Run to Dana Point (California) | 2,262.45 mi (3,641.06 km) |
| Difficult Run to Danbury (Connecticut) | 267.79 mi (430.97 km) |
| Difficult Run to Dania Beach (Florida) | 902.24 mi (1,452.01 km) |
| Difficult Run to Danville (California) | 2,394.39 mi (3,853.40 km) |
| Difficult Run to Danville (Illinois) | 553.40 mi (890.60 km) |
| Difficult Run to Danville (Indiana) | 492.62 mi (792.79 km) |
| Difficult Run to Danville (Kentucky) | 412.23 mi (663.42 km) |
| Difficult Run to Danville (Virginia) | 195.82 mi (315.14 km) |
| Difficult Run to Daphne (Alabama) | 826.20 mi (1,329.64 km) |
