| Difficult Run to Crawfordsville (Indiana) | 515.19 mi (829.11 km) |
| Difficult Run to Crest Hill (Illinois) | 596.55 mi (960.06 km) |
| Difficult Run to Crestview (Florida) | 768.26 mi (1,236.39 km) |
| Difficult Run to Crestwood (Illinois) | 579.28 mi (932.25 km) |
| Difficult Run to Crestwood (Missouri) | 702.19 mi (1,130.07 km) |
| Difficult Run to Creve Coeur (Missouri) | 704.94 mi (1,134.50 km) |
| Difficult Run to Crofton (Maryland) | 36.68 mi (59.03 km) |
| Difficult Run to Crossville (Tennessee) | 467.97 mi (753.12 km) |
| Difficult Run to Crowley (Louisiana) | 1,042.34 mi (1,677.49 km) |
| Difficult Run to Crowley (Texas) | 1,201.13 mi (1,933.03 km) |
| Difficult Run to Crown Point (Indiana) | 555.40 mi (893.84 km) |
| Difficult Run to Crystal (Minnesota) | 923.15 mi (1,485.67 km) |
| Difficult Run to Crystal Lake (Illinois) | 620.37 mi (998.39 km) |
| Difficult Run to Cudahy (California) | 2,276.42 mi (3,663.54 km) |
| Difficult Run to Cudahy (Wisconsin) | 615.46 mi (990.49 km) |
