| Difficult Run to Commerce (California) | 2,273.94 mi (3,659.56 km) |
| Difficult Run to Commerce City (Colorado) | 1,464.10 mi (2,356.24 km) |
| Difficult Run to Compton (California) | 2,280.51 mi (3,670.13 km) |
| Difficult Run to Comstock Park (Michigan) | 519.97 mi (836.80 km) |
| Difficult Run to Concord (California) | 2,393.03 mi (3,851.21 km) |
| Difficult Run to Concord (Missouri) | 701.41 mi (1,128.80 km) |
| Difficult Run to Concord (New Hampshire) | 424.48 mi (683.13 km) |
| Difficult Run to Concord (North Carolina) | 302.58 mi (486.95 km) |
| Difficult Run to Conneaut (Ohio) | 269.08 mi (433.04 km) |
| Difficult Run to Connersville (Indiana) | 419.97 mi (675.87 km) |
| Difficult Run to Conroe (Texas) | 1,186.18 mi (1,908.97 km) |
| Difficult Run to Converse (Texas) | 1,357.58 mi (2,184.81 km) |
| Difficult Run to Conway (Arkansas) | 874.20 mi (1,406.89 km) |
| Difficult Run to Conway (Florida) | 754.28 mi (1,213.89 km) |
| Difficult Run to Conway (South Carolina) | 362.20 mi (582.90 km) |
