| Difficult Run to Channelview (Texas) | 1,189.82 mi (1,914.83 km) |
| Difficult Run to Chantilly (Virginia) | 5.38 mi (8.66 km) |
| Difficult Run to Chaparral (New Mexico) | 1,694.23 mi (2,726.60 km) |
| Difficult Run to Chapel Hill (North Carolina) | 225.51 mi (362.92 km) |
| Difficult Run to Charleston (Illinois) | 581.03 mi (935.08 km) |
| Difficult Run to Charleston (South Carolina) | 445.25 mi (716.56 km) |
| Difficult Run to Charleston (West Virginia) | 234.42 mi (377.26 km) |
| Difficult Run to Charlotte (North Carolina) | 319.32 mi (513.90 km) |
| Difficult Run to Charlottesville (Virginia) | 85.77 mi (138.04 km) |
| Difficult Run to Chaska (Minnesota) | 929.03 mi (1,495.13 km) |
| Difficult Run to Chatham (Illinois) | 661.86 mi (1,065.17 km) |
| Difficult Run to Chattanooga (Tennessee) | 509.99 mi (820.75 km) |
| Difficult Run to Cheat Lake (West Virginia) | 144.23 mi (232.12 km) |
| Difficult Run to Chelsea (Alabama) | 645.07 mi (1,038.14 km) |
| Difficult Run to Chelsea (Massachusetts) | 409.53 mi (659.07 km) |
