| Difficult Run to Central Point (Oregon) | 2,372.31 mi (3,817.86 km) |
| Difficult Run to Centralia (Illinois) | 634.99 mi (1,021.92 km) |
| Difficult Run to Centralia (Washington) | 2,340.08 mi (3,766.00 km) |
| Difficult Run to Centreville (Virginia) | 6.56 mi (10.56 km) |
| Difficult Run to Ceres (California) | 2,345.55 mi (3,774.80 km) |
| Difficult Run to Cerritos (California) | 2,272.61 mi (3,657.42 km) |
| Difficult Run to Chalco (Nebraska) | 1,004.20 mi (1,616.11 km) |
| Difficult Run to Chalmette (Louisiana) | 947.16 mi (1,524.31 km) |
| Difficult Run to Chambersburg (Pennsylvania) | 73.04 mi (117.55 km) |
| Difficult Run to Chamblee (Georgia) | 519.07 mi (835.36 km) |
| Difficult Run to Champaign (Illinois) | 588.08 mi (946.43 km) |
| Difficult Run to Champlin (Minnesota) | 927.95 mi (1,493.39 km) |
| Difficult Run to Chandler (Arizona) | 1,953.08 mi (3,143.18 km) |
| Difficult Run to Chanhassen (Minnesota) | 927.80 mi (1,493.15 km) |
| Difficult Run to Channahon (Illinois) | 601.46 mi (967.96 km) |
