| Difficult Run to Cedar Park (Texas) | 1,295.28 mi (2,084.55 km) |
| Difficult Run to Cedar Rapids (Iowa) | 781.79 mi (1,258.17 km) |
| Difficult Run to Cedarburg (Wisconsin) | 631.21 mi (1,015.83 km) |
| Difficult Run to Celebration (Florida) | 770.49 mi (1,239.98 km) |
| Difficult Run to Celina (Ohio) | 399.94 mi (643.64 km) |
| Difficult Run to Celina (Texas) | 1,149.35 mi (1,849.69 km) |
| Difficult Run to Centennial (Colorado) | 1,467.55 mi (2,361.79 km) |
| Difficult Run to Center Point (Alabama) | 633.87 mi (1,020.11 km) |
| Difficult Run to Centereach (New York) | 263.75 mi (424.47 km) |
| Difficult Run to Centerton (Arkansas) | 942.58 mi (1,516.94 km) |
| Difficult Run to Centerville (Ohio) | 367.04 mi (590.69 km) |
| Difficult Run to Centerville (Utah) | 1,823.76 mi (2,935.05 km) |
| Difficult Run to Central (Louisiana) | 965.90 mi (1,554.47 km) |
| Difficult Run to Central Falls (Rhode Island) | 375.07 mi (603.62 km) |
| Difficult Run to Central Islip (New York) | 255.77 mi (411.62 km) |
