| Difficult Run to Candler-McAfee (Georgia) | 525.52 mi (845.74 km) |
| Difficult Run to Caño Martin Peña (Puerto Rico) | 1,568.32 mi (2,523.96 km) |
| Difficult Run to Cañon City (Colorado) | 1,498.03 mi (2,410.85 km) |
| Difficult Run to Canóvanas (Puerto Rico) | 1,576.12 mi (2,536.52 km) |
| Difficult Run to Canton (Georgia) | 510.11 mi (820.95 km) |
| Difficult Run to Canton (Illinois) | 683.56 mi (1,100.09 km) |
| Difficult Run to Canton (Mississippi) | 832.85 mi (1,340.34 km) |
| Difficult Run to Canton (Ohio) | 250.60 mi (403.31 km) |
| Difficult Run to Canyon (Texas) | 1,379.06 mi (2,219.38 km) |
| Difficult Run to Canyon Lake (California) | 2,233.75 mi (3,594.88 km) |
| Difficult Run to Canyon Lake (Texas) | 1,341.15 mi (2,158.37 km) |
| Difficult Run to Cape Coral (Florida) | 888.56 mi (1,429.99 km) |
| Difficult Run to Cape Girardeau (Missouri) | 672.47 mi (1,082.23 km) |
| Difficult Run to Carbondale (Illinois) | 648.54 mi (1,043.73 km) |
| Difficult Run to Carlisle (Pennsylvania) | 90.04 mi (144.90 km) |
