| Difficult Run to Anoka (Minnesota) | 928.94 mi (1,494.99 km) |
| Difficult Run to Ansonia (Connecticut) | 282.03 mi (453.88 km) |
| Difficult Run to Antelope (California) | 2,346.11 mi (3,775.70 km) |
| Difficult Run to Anthem (Arizona) | 1,953.20 mi (3,143.36 km) |
| Difficult Run to Antioch (California) | 2,382.13 mi (3,833.67 km) |
| Difficult Run to Antioch (Illinois) | 613.14 mi (986.75 km) |
| Difficult Run to Apache Junction (Arizona) | 1,933.15 mi (3,111.11 km) |
| Difficult Run to Apex (North Carolina) | 235.05 mi (378.28 km) |
| Difficult Run to Apollo Beach (Florida) | 822.73 mi (1,324.05 km) |
| Difficult Run to Apopka (Florida) | 744.34 mi (1,197.90 km) |
| Difficult Run to Apple Valley (California) | 2,210.67 mi (3,557.73 km) |
| Difficult Run to Apple Valley (Minnesota) | 908.55 mi (1,462.17 km) |
| Difficult Run to Appleton (Wisconsin) | 679.96 mi (1,094.28 km) |
| Difficult Run to Arbutus (Maryland) | 42.31 mi (68.09 km) |
| Difficult Run to Arcadia (California) | 2,264.46 mi (3,644.30 km) |
