| Difficult Run to Anderson (California) | 2,366.65 mi (3,808.75 km) |
| Difficult Run to Anderson (Indiana) | 452.11 mi (727.59 km) |
| Difficult Run to Anderson (South Carolina) | 421.51 mi (678.36 km) |
| Difficult Run to Anderson Creek (North Carolina) | 266.43 mi (428.78 km) |
| Difficult Run to Andover (Kansas) | 1,074.21 mi (1,728.77 km) |
| Difficult Run to Andover (Minnesota) | 927.37 mi (1,492.45 km) |
| Difficult Run to Andrews (Texas) | 1,481.41 mi (2,384.10 km) |
| Difficult Run to Angleton (Texas) | 1,230.80 mi (1,980.78 km) |
| Difficult Run to Ankeny (Iowa) | 876.97 mi (1,411.35 km) |
| Difficult Run to Ann Arbor (Michigan) | 407.92 mi (656.49 km) |
| Difficult Run to Anna (Texas) | 1,135.70 mi (1,827.74 km) |
| Difficult Run to Annandale (Virginia) | 9.43 mi (15.18 km) |
| Difficult Run to Annapolis (Maryland) | 45.52 mi (73.26 km) |
| Difficult Run to Annapolis Neck (Maryland) | 45.63 mi (73.44 km) |
| Difficult Run to Anniston (Alabama) | 593.63 mi (955.35 km) |
