| Difficult Run to Altus (Oklahoma) | 1,246.77 mi (2,006.49 km) |
| Difficult Run to Alum Rock (California) | 2,395.28 mi (3,854.84 km) |
| Difficult Run to Alvin (Texas) | 1,215.25 mi (1,955.76 km) |
| Difficult Run to Amarillo (Texas) | 1,369.87 mi (2,204.60 km) |
| Difficult Run to Amelia (Ohio) | 369.34 mi (594.40 km) |
| Difficult Run to American Canyon (California) | 2,402.61 mi (3,866.62 km) |
| Difficult Run to American Fork (Utah) | 1,824.11 mi (2,935.62 km) |
| Difficult Run to Americus (Georgia) | 609.73 mi (981.27 km) |
| Difficult Run to Ames (Iowa) | 880.82 mi (1,417.54 km) |
| Difficult Run to Amherst (Ohio) | 310.33 mi (499.43 km) |
| Difficult Run to Ammon (Idaho) | 1,813.64 mi (2,918.76 km) |
| Difficult Run to Amsterdam (New York) | 324.11 mi (521.61 km) |
| Difficult Run to Anacortes (Washington) | 2,319.80 mi (3,733.35 km) |
| Difficult Run to Anaheim (California) | 2,261.99 mi (3,640.32 km) |
| Difficult Run to Anchorage (Alaska) | 3,324.81 mi (5,350.76 km) |
