| Difficult Run to Abilene (Texas) | 1,329.14 mi (2,139.05 km) |
| Difficult Run to Accokeek (Maryland) | 24.31 mi (39.13 km) |
| Difficult Run to Acworth (Georgia) | 526.60 mi (847.48 km) |
| Difficult Run to Ada (Oklahoma) | 1,103.64 mi (1,776.13 km) |
| Difficult Run to Addison (Illinois) | 598.12 mi (962.57 km) |
| Difficult Run to Addison (Texas) | 1,162.18 mi (1,870.35 km) |
| Difficult Run to Adelanto (California) | 2,221.85 mi (3,575.73 km) |
| Difficult Run to Adelphi (Maryland) | 21.67 mi (34.87 km) |
| Difficult Run to Adrian (Michigan) | 408.59 mi (657.56 km) |
| Difficult Run to Affton (Missouri) | 699.46 mi (1,125.67 km) |
| Difficult Run to Agoura Hills (California) | 2,302.83 mi (3,706.05 km) |
| Difficult Run to Aguadilla (Puerto Rico) | 1,540.44 mi (2,479.09 km) |
| Difficult Run to Aiken (South Carolina) | 444.10 mi (714.70 km) |
| Difficult Run to Akron (Ohio) | 267.32 mi (430.22 km) |
| Difficult Run to Alabaster (Alabama) | 658.33 mi (1,059.48 km) |
