| Difficult Run to Schaffhausen | 4,140.15 mi (6,662.93 km) |
| Difficult Run to Schlieren | 4,141.65 mi (6,665.34 km) |
| Difficult Run to Schubelbach | 4,168.62 mi (6,708.74 km) |
| Difficult Run to Schwyz | 4,161.84 mi (6,697.84 km) |
| Difficult Run to Sierre | 4,136.49 mi (6,657.04 km) |
| Difficult Run to Sion | 4,131.40 mi (6,648.85 km) |
| Difficult Run to Solothurn | 4,108.63 mi (6,612.21 km) |
| Difficult Run to Spiez | 4,130.46 mi (6,647.33 km) |
| Difficult Run to Spreitenbach | 4,137.65 mi (6,658.90 km) |
| Difficult Run to Stafa | 4,158.31 mi (6,692.16 km) |
| Difficult Run to Stans | 4,151.25 mi (6,680.78 km) |
| Difficult Run to Steffisburg | 4,126.50 mi (6,640.96 km) |
| Difficult Run to Stegen | 4,152.72 mi (6,683.16 km) |
| Difficult Run to Steinhaus | 4,149.39 mi (6,677.80 km) |
| Difficult Run to Suhr | 4,126.91 mi (6,641.62 km) |
