| Difficult Run to Noventa Vicentina | 4,339.76 mi (6,984.16 km) |
| Difficult Run to Novi di Modena | 4,325.78 mi (6,961.66 km) |
| Difficult Run to Novi Ligure | 4,238.90 mi (6,821.85 km) |
| Difficult Run to Nuoro | 4,411.82 mi (7,100.14 km) |
| Difficult Run to Occhiobello | 4,353.94 mi (7,006.99 km) |
| Difficult Run to Oderzo | 4,363.59 mi (7,022.51 km) |
| Difficult Run to Oggiono | 4,230.34 mi (6,808.07 km) |
| Difficult Run to Olbia | 4,398.69 mi (7,079.00 km) |
| Difficult Run to Oleggio | 4,205.47 mi (6,768.05 km) |
| Difficult Run to Olgiate Comasco | 4,213.95 mi (6,781.70 km) |
| Difficult Run to Olgiate Olona | 4,215.14 mi (6,783.62 km) |
| Difficult Run to Omegna | 4,186.99 mi (6,738.30 km) |
| Difficult Run to Opera | 4,237.45 mi (6,819.51 km) |
| Difficult Run to Oppeano | 4,324.30 mi (6,959.29 km) |
| Difficult Run to Orbassano | 4,176.73 mi (6,721.80 km) |
