| Destrehan to Southern Pines (North Carolina) | 732.84 mi (1,179.40 km) |
| Destrehan to Southfield (Michigan) | 950.17 mi (1,529.15 km) |
| Destrehan to Southgate (Michigan) | 934.74 mi (1,504.31 km) |
| Destrehan to Southlake (Texas) | 449.90 mi (724.05 km) |
| Destrehan to Spanaway (Washington) | 2,075.44 mi (3,340.10 km) |
| Destrehan to Spanish Fork (Utah) | 1,387.44 mi (2,232.86 km) |
| Destrehan to Spanish Lake (Missouri) | 609.87 mi (981.49 km) |
| Destrehan to Spanish Springs (Nevada) | 1,782.03 mi (2,867.90 km) |
| Destrehan to Sparks (Nevada) | 1,783.18 mi (2,869.74 km) |
| Destrehan to Spartanburg (South Carolina) | 600.24 mi (965.99 km) |
| Destrehan to Spearfish (South Dakota) | 1,243.39 mi (2,001.05 km) |
| Destrehan to Speedway (Indiana) | 718.04 mi (1,155.58 km) |
| Destrehan to Spencer (Iowa) | 948.43 mi (1,526.35 km) |
| Destrehan to Spokane (Washington) | 1,885.15 mi (3,033.85 km) |
| Destrehan to Spokane Valley (Washington) | 1,877.06 mi (3,020.84 km) |
