| Destrehan to Silver Firs (Washington) | 2,085.34 mi (3,356.02 km) |
| Destrehan to Silver Spring (Maryland) | 981.96 mi (1,580.30 km) |
| Destrehan to Silver Springs Shores (Florida) | 505.42 mi (813.39 km) |
| Destrehan to Silverdale (Washington) | 2,102.28 mi (3,383.29 km) |
| Destrehan to Silverton (Oregon) | 2,038.64 mi (3,280.88 km) |
| Destrehan to Simi Valley (California) | 1,681.67 mi (2,706.39 km) |
| Destrehan to Simpsonville (South Carolina) | 576.37 mi (927.57 km) |
| Destrehan to Sioux City (Iowa) | 928.09 mi (1,493.62 km) |
| Destrehan to Sioux Falls (South Dakota) | 1,001.25 mi (1,611.35 km) |
| Destrehan to Skokie (Illinois) | 846.90 mi (1,362.95 km) |
| Destrehan to Sleepy Hollow (New York) | 1,201.22 mi (1,933.18 km) |
| Destrehan to Slidell (Louisiana) | 41.58 mi (66.92 km) |
| Destrehan to Smithfield (North Carolina) | 795.97 mi (1,280.98 km) |
| Destrehan to Smithfield (Utah) | 1,447.83 mi (2,330.06 km) |
| Destrehan to Smithville (Missouri) | 693.74 mi (1,116.47 km) |
