| Destrehan to Olympia Heights (Florida) | 678.71 mi (1,092.28 km) |
| Destrehan to Omaha (Nebraska) | 843.03 mi (1,356.73 km) |
| Destrehan to On Top of the World Designated Place (Florida) | 489.28 mi (787.42 km) |
| Destrehan to Onalaska (Wisconsin) | 963.28 mi (1,550.24 km) |
| Destrehan to Oneida (New York) | 1,216.04 mi (1,957.03 km) |
| Destrehan to Oneonta (New York) | 1,209.80 mi (1,946.98 km) |
| Destrehan to Ontario (California) | 1,615.74 mi (2,600.29 km) |
| Destrehan to Ontario (Oregon) | 1,748.34 mi (2,813.68 km) |
| Destrehan to Opa-locka (Florida) | 677.77 mi (1,090.76 km) |
| Destrehan to Opelika (Alabama) | 348.58 mi (560.98 km) |
| Destrehan to Opelousas (Louisiana) | 109.44 mi (176.13 km) |
| Destrehan to Orange (California) | 1,627.47 mi (2,619.16 km) |
| Destrehan to Orange (Texas) | 203.24 mi (327.08 km) |
| Destrehan to Orange City (Florida) | 550.72 mi (886.30 km) |
| Destrehan to Orangeburg (South Carolina) | 608.94 mi (980.00 km) |
