| Destrehan to Enumclaw (Washington) | 2,059.65 mi (3,314.69 km) |
| Destrehan to Ephrata (Pennsylvania) | 1,066.16 mi (1,715.82 km) |
| Destrehan to Erie (Colorado) | 1,081.10 mi (1,739.86 km) |
| Destrehan to Erie (Pennsylvania) | 1,016.10 mi (1,635.26 km) |
| Destrehan to Erlanger (Kentucky) | 706.17 mi (1,136.47 km) |
| Destrehan to Escanaba (Michigan) | 1,104.94 mi (1,778.24 km) |
| Destrehan to Escondido (California) | 1,583.26 mi (2,548.01 km) |
| Destrehan to Española (New Mexico) | 999.53 mi (1,608.59 km) |
| Destrehan to Essex (Maryland) | 1,019.08 mi (1,640.06 km) |
| Destrehan to Essex Junction (Vermont) | 1,375.79 mi (2,214.12 km) |
| Destrehan to Estelle (Louisiana) | 17.87 mi (28.75 km) |
| Destrehan to Estero (Florida) | 576.10 mi (927.14 km) |
| Destrehan to Euclid (Ohio) | 942.95 mi (1,517.53 km) |
| Destrehan to Eufaula (Alabama) | 337.15 mi (542.58 km) |
| Destrehan to Eugene (Oregon) | 2,033.64 mi (3,272.82 km) |
