| Des Moines to Yonkers (New York) | 1,024.13 mi (1,648.18 km) |
| Des Moines to Yorba Linda (California) | 1,417.01 mi (2,280.45 km) |
| Des Moines to York (Pennsylvania) | 888.75 mi (1,430.30 km) |
| Des Moines to Yorktown (Indiana) | 433.64 mi (697.88 km) |
| Des Moines to Yorkville (Illinois) | 266.56 mi (428.99 km) |
| Des Moines to Youngstown (Ohio) | 672.73 mi (1,082.65 km) |
| Des Moines to Youngsville (Louisiana) | 798.02 mi (1,284.29 km) |
| Des Moines to Ypsilanti (Michigan) | 515.46 mi (829.56 km) |
| Des Moines to Yuba City (California) | 1,478.76 mi (2,379.84 km) |
| Des Moines to Yucaipa (California) | 1,375.67 mi (2,213.92 km) |
| Des Moines to Yucca Valley (California) | 1,341.60 mi (2,159.10 km) |
| Des Moines to Yukon (Oklahoma) | 474.45 mi (763.56 km) |
| Des Moines to Yulee (Florida) | 1,009.40 mi (1,624.48 km) |
| Des Moines to Yuma (Arizona) | 1,305.17 mi (2,100.46 km) |
| Des Moines to Zachary (Louisiana) | 765.86 mi (1,232.54 km) |
