| Des Moines to Worthington (Ohio) | 562.54 mi (905.32 km) |
| Des Moines to Wright (Florida) | 861.14 mi (1,385.87 km) |
| Des Moines to Wyandanch (New York) | 1,052.33 mi (1,693.56 km) |
| Des Moines to Wyandotte (Michigan) | 539.19 mi (867.74 km) |
| Des Moines to Wylie (Texas) | 610.93 mi (983.20 km) |
| Des Moines to Wyndham (Virginia) | 890.96 mi (1,433.87 km) |
| Des Moines to Wyoming (Michigan) | 414.32 mi (666.78 km) |
| Des Moines to Wyomissing (Pennsylvania) | 922.89 mi (1,485.24 km) |
| Des Moines to Xenia (Ohio) | 523.26 mi (842.11 km) |
| Des Moines to Yakima (Washington) | 1,373.90 mi (2,211.07 km) |
| Des Moines to Yankton (South Dakota) | 213.81 mi (344.10 km) |
| Des Moines to Yauco (Puerto Rico) | 2,265.51 mi (3,645.98 km) |
| Des Moines to Yazoo City (Mississippi) | 626.98 mi (1,009.03 km) |
| Des Moines to Yeadon (Pennsylvania) | 965.66 mi (1,554.09 km) |
| Des Moines to Yelm (Washington) | 1,473.72 mi (2,371.72 km) |
