| Des Moines to University Place (Washington) | 1,471.39 mi (2,367.97 km) |
| Des Moines to Upland (California) | 1,403.81 mi (2,259.22 km) |
| Des Moines to Upper Arlington (Ohio) | 561.15 mi (903.08 km) |
| Des Moines to Upper Grand Lagoon (Florida) | 901.77 mi (1,451.26 km) |
| Des Moines to Upper Montclair (New Jersey) | 1,008.07 mi (1,622.33 km) |
| Des Moines to Urbana (Illinois) | 300.37 mi (483.40 km) |
| Des Moines to Urbana (Maryland) | 867.94 mi (1,396.81 km) |
| Des Moines to Urbana (Ohio) | 524.73 mi (844.47 km) |
| Des Moines to Urbandale (Iowa) | 9.94 mi (16.00 km) |
| Des Moines to Utica (New York) | 942.96 mi (1,517.54 km) |
| Des Moines to Uvalde (Texas) | 921.11 mi (1,482.39 km) |
| Des Moines to Vacaville (California) | 1,511.02 mi (2,431.76 km) |
| Des Moines to Vadnais Heights (Minnesota) | 242.26 mi (389.87 km) |
| Des Moines to Vail (Arizona) | 1,149.29 mi (1,849.60 km) |
| Des Moines to Valdosta (Georgia) | 936.87 mi (1,507.75 km) |
