| Des Moines to Superior (Colorado) | 614.45 mi (988.87 km) |
| Des Moines to Superior (Wisconsin) | 361.87 mi (582.38 km) |
| Des Moines to Surprise (Arizona) | 1,162.75 mi (1,871.26 km) |
| Des Moines to Susanville (California) | 1,404.65 mi (2,260.56 km) |
| Des Moines to Sussex (Wisconsin) | 295.45 mi (475.48 km) |
| Des Moines to Suwanee (Georgia) | 734.88 mi (1,182.67 km) |
| Des Moines to Swansea (Illinois) | 283.37 mi (456.04 km) |
| Des Moines to Sweetwater (Florida) | 1,326.85 mi (2,135.36 km) |
| Des Moines to Sweetwater (Texas) | 731.72 mi (1,177.59 km) |
| Des Moines to Sycamore (Illinois) | 255.55 mi (411.27 km) |
| Des Moines to Sylacauga (Alabama) | 705.96 mi (1,136.14 km) |
| Des Moines to Sylvania (Ohio) | 511.06 mi (822.47 km) |
| Des Moines to Syosset (New York) | 1,044.41 mi (1,680.82 km) |
| Des Moines to Syracuse (New York) | 896.62 mi (1,442.97 km) |
| Des Moines to Syracuse (Utah) | 956.51 mi (1,539.35 km) |
