| Des Moines to Storm Lake (Iowa) | 109.89 mi (176.85 km) |
| Des Moines to Storrs (Connecticut) | 1,099.31 mi (1,769.16 km) |
| Des Moines to Stoughton (Wisconsin) | 243.03 mi (391.12 km) |
| Des Moines to Stow (Ohio) | 631.37 mi (1,016.10 km) |
| Des Moines to Streamwood (Illinois) | 281.49 mi (453.02 km) |
| Des Moines to Streator (Illinois) | 249.87 mi (402.12 km) |
| Des Moines to Streetsboro (Ohio) | 635.48 mi (1,022.71 km) |
| Des Moines to Strongsville (Ohio) | 609.88 mi (981.50 km) |
| Des Moines to Stuart (Florida) | 1,248.74 mi (2,009.66 km) |
| Des Moines to Stuarts Draft (Virginia) | 810.58 mi (1,304.51 km) |
| Des Moines to Sturgis (Michigan) | 422.83 mi (680.49 km) |
| Des Moines to Suamico (Wisconsin) | 350.51 mi (564.09 km) |
| Des Moines to Sudley (Virginia) | 870.75 mi (1,401.33 km) |
| Des Moines to Suffern (New York) | 1,008.24 mi (1,622.60 km) |
| Des Moines to Suffolk (Virginia) | 967.93 mi (1,557.73 km) |
