| Des Moines to Stephenville (Texas) | 694.64 mi (1,117.92 km) |
| Des Moines to Sterling (Colorado) | 502.97 mi (809.46 km) |
| Des Moines to Sterling (Illinois) | 202.60 mi (326.05 km) |
| Des Moines to Sterling (Virginia) | 870.93 mi (1,401.62 km) |
| Des Moines to Sterling Heights (Michigan) | 546.68 mi (879.79 km) |
| Des Moines to Steubenville (Ohio) | 680.52 mi (1,095.19 km) |
| Des Moines to Stevens Point (Wisconsin) | 289.08 mi (465.23 km) |
| Des Moines to Stevenson Ranch (California) | 1,441.76 mi (2,320.28 km) |
| Des Moines to Stillwater (Minnesota) | 243.94 mi (392.58 km) |
| Des Moines to Stillwater (Oklahoma) | 419.49 mi (675.10 km) |
| Des Moines to Stockbridge (Georgia) | 756.17 mi (1,216.94 km) |
| Des Moines to Stockton (California) | 1,485.22 mi (2,390.23 km) |
| Des Moines to Stone Ridge (Virginia) | 864.73 mi (1,391.65 km) |
| Des Moines to Stonecrest (Georgia) | 751.25 mi (1,209.02 km) |
| Des Moines to Stony Brook (New York) | 1,062.69 mi (1,710.23 km) |
