| Des Moines to St. Simons (Georgia) | 987.11 mi (1,588.60 km) |
| Des Moines to Stafford (Texas) | 832.56 mi (1,339.87 km) |
| Des Moines to Stallings (North Carolina) | 830.48 mi (1,336.53 km) |
| Des Moines to Stamford (Connecticut) | 1,038.40 mi (1,671.14 km) |
| Des Moines to Stanford (California) | 1,541.89 mi (2,481.44 km) |
| Des Moines to Stanton (California) | 1,431.12 mi (2,303.17 km) |
| Des Moines to Star (Idaho) | 1,168.50 mi (1,880.52 km) |
| Des Moines to Starkville (Mississippi) | 618.41 mi (995.24 km) |
| Des Moines to State College (Pennsylvania) | 819.86 mi (1,319.43 km) |
| Des Moines to Staten Island (New York) | 1,013.74 mi (1,631.46 km) |
| Des Moines to Statesboro (Georgia) | 906.55 mi (1,458.95 km) |
| Des Moines to Statesville (North Carolina) | 793.83 mi (1,277.55 km) |
| Des Moines to Staunton (Virginia) | 805.67 mi (1,296.60 km) |
| Des Moines to Steamboat Springs (Colorado) | 692.23 mi (1,114.03 km) |
| Des Moines to Steiner Ranch (Texas) | 810.27 mi (1,304.01 km) |
