| Des Moines to Spout Springs (North Carolina) | 899.46 mi (1,447.54 km) |
| Des Moines to Spring (Texas) | 801.47 mi (1,289.84 km) |
| Des Moines to Spring Creek (Nevada) | 1,142.13 mi (1,838.08 km) |
| Des Moines to Spring Hill (Florida) | 1,098.51 mi (1,767.88 km) |
| Des Moines to Spring Hill (Tennessee) | 540.78 mi (870.30 km) |
| Des Moines to Spring Lake (North Carolina) | 904.55 mi (1,455.74 km) |
| Des Moines to Spring Valley (California) | 1,418.27 mi (2,282.48 km) |
| Des Moines to Spring Valley (Nevada) | 1,221.45 mi (1,965.73 km) |
| Des Moines to Spring Valley (New York) | 1,013.04 mi (1,630.34 km) |
| Des Moines to Springboro (Ohio) | 511.04 mi (822.43 km) |
| Des Moines to Springdale (Arkansas) | 373.05 mi (600.36 km) |
| Des Moines to Springdale (New Jersey) | 981.00 mi (1,578.77 km) |
| Des Moines to Springdale (Ohio) | 505.31 mi (813.22 km) |
| Des Moines to Springfield (Illinois) | 241.80 mi (389.13 km) |
| Des Moines to Springfield (Massachusetts) | 1,082.47 mi (1,742.06 km) |
