| Des Moines to Southern Pines (North Carolina) | 885.11 mi (1,424.44 km) |
| Des Moines to Southfield (Michigan) | 534.55 mi (860.27 km) |
| Des Moines to Southgate (Michigan) | 536.63 mi (863.62 km) |
| Des Moines to Southlake (Texas) | 626.29 mi (1,007.92 km) |
| Des Moines to Spanaway (Washington) | 1,464.99 mi (2,357.67 km) |
| Des Moines to Spanish Fork (Utah) | 946.10 mi (1,522.60 km) |
| Des Moines to Spanish Lake (Missouri) | 263.15 mi (423.49 km) |
| Des Moines to Spanish Springs (Nevada) | 1,367.93 mi (2,201.47 km) |
| Des Moines to Sparks (Nevada) | 1,371.75 mi (2,207.61 km) |
| Des Moines to Spartanburg (South Carolina) | 780.93 mi (1,256.78 km) |
| Des Moines to Spearfish (South Dakota) | 552.97 mi (889.91 km) |
| Des Moines to Speedway (Indiana) | 404.71 mi (651.31 km) |
| Des Moines to Spencer (Iowa) | 134.30 mi (216.13 km) |
| Des Moines to Spokane (Washington) | 1,238.96 mi (1,993.92 km) |
| Des Moines to Spokane Valley (Washington) | 1,229.85 mi (1,979.25 km) |
