| Des Moines to South Plainfield (New Jersey) | 1,000.13 mi (1,609.56 km) |
| Des Moines to South Portland (Maine) | 1,190.58 mi (1,916.05 km) |
| Des Moines to South Riding (Virginia) | 867.27 mi (1,395.74 km) |
| Des Moines to South River (New Jersey) | 1,003.67 mi (1,615.25 km) |
| Des Moines to South Salt Lake (Utah) | 951.72 mi (1,531.65 km) |
| Des Moines to South San Francisco (California) | 1,549.69 mi (2,493.98 km) |
| Des Moines to South San Jose Hills (California) | 1,419.56 mi (2,284.56 km) |
| Des Moines to South Sioux City (Nebraska) | 156.42 mi (251.74 km) |
| Des Moines to South St. Paul (Minnesota) | 230.84 mi (371.51 km) |
| Des Moines to South Valley (New Mexico) | 840.06 mi (1,351.94 km) |
| Des Moines to South Venice (Florida) | 1,187.50 mi (1,911.09 km) |
| Des Moines to South Whittier (California) | 1,428.55 mi (2,299.03 km) |
| Des Moines to South Yarmouth (Massachusetts) | 1,205.43 mi (1,939.95 km) |
| Des Moines to Southaven (Mississippi) | 497.97 mi (801.41 km) |
| Des Moines to Southchase (Florida) | 1,141.82 mi (1,837.58 km) |
