| Des Moines to Somersworth (New Hampshire) | 1,161.43 mi (1,869.14 km) |
| Des Moines to Somerton (Arizona) | 1,312.35 mi (2,112.02 km) |
| Des Moines to Somerville (Massachusetts) | 1,154.09 mi (1,857.33 km) |
| Des Moines to Somerville (New Jersey) | 990.18 mi (1,593.54 km) |
| Des Moines to Sonoma (California) | 1,537.90 mi (2,475.02 km) |
| Des Moines to Soquel (California) | 1,540.74 mi (2,479.58 km) |
| Des Moines to South Bend (Indiana) | 379.10 mi (610.10 km) |
| Des Moines to South Bradenton (Florida) | 1,157.40 mi (1,862.65 km) |
| Des Moines to South Burlington (Vermont) | 1,046.35 mi (1,683.94 km) |
| Des Moines to South Charleston (West Virginia) | 667.65 mi (1,074.48 km) |
| Des Moines to South Daytona (Florida) | 1,110.65 mi (1,787.42 km) |
| Des Moines to South El Monte (California) | 1,425.58 mi (2,294.24 km) |
| Des Moines to South Elgin (Illinois) | 274.39 mi (441.59 km) |
| Des Moines to South Euclid (Ohio) | 624.46 mi (1,004.96 km) |
| Des Moines to South Farmingdale (New York) | 1,048.38 mi (1,687.20 km) |
