| Des Moines to Smyrna (Delaware) | 957.95 mi (1,541.66 km) |
| Des Moines to Smyrna (Georgia) | 727.67 mi (1,171.08 km) |
| Des Moines to Smyrna (Tennessee) | 543.26 mi (874.29 km) |
| Des Moines to Snellville (Georgia) | 747.36 mi (1,202.76 km) |
| Des Moines to Snoqualmie (Washington) | 1,440.61 mi (2,318.43 km) |
| Des Moines to Snyder (Texas) | 731.73 mi (1,177.60 km) |
| Des Moines to Socastee (South Carolina) | 964.97 mi (1,552.97 km) |
| Des Moines to Socorro (Texas) | 979.49 mi (1,576.33 km) |
| Des Moines to Soddy-Daisy (Tennessee) | 631.07 mi (1,015.61 km) |
| Des Moines to Solana Beach (California) | 1,422.55 mi (2,289.38 km) |
| Des Moines to Soledad (California) | 1,523.40 mi (2,451.68 km) |
| Des Moines to Solon (Ohio) | 629.61 mi (1,013.25 km) |
| Des Moines to Somers Point (New Jersey) | 1,009.23 mi (1,624.20 km) |
| Des Moines to Somerset (Kentucky) | 571.85 mi (920.30 km) |
| Des Moines to Somerset (New Jersey) | 996.53 mi (1,603.76 km) |
