| Des Moines to Silver Firs (Washington) | 1,457.45 mi (2,345.55 km) |
| Des Moines to Silver Spring (Maryland) | 890.72 mi (1,433.48 km) |
| Des Moines to Silver Springs Shores (Florida) | 1,078.66 mi (1,735.94 km) |
| Des Moines to Silverdale (Washington) | 1,480.59 mi (2,382.78 km) |
| Des Moines to Silverton (Oregon) | 1,477.89 mi (2,378.43 km) |
| Des Moines to Simi Valley (California) | 1,453.83 mi (2,339.71 km) |
| Des Moines to Simpsonville (South Carolina) | 776.13 mi (1,249.07 km) |
| Des Moines to Sioux City (Iowa) | 156.25 mi (251.46 km) |
| Des Moines to Sioux Falls (South Dakota) | 209.01 mi (336.37 km) |
| Des Moines to Skokie (Illinois) | 303.98 mi (489.22 km) |
| Des Moines to Sleepy Hollow (New York) | 1,022.35 mi (1,645.31 km) |
| Des Moines to Slidell (Louisiana) | 808.27 mi (1,300.79 km) |
| Des Moines to Smithfield (North Carolina) | 923.05 mi (1,485.50 km) |
| Des Moines to Smithfield (Utah) | 938.08 mi (1,509.69 km) |
| Des Moines to Smithville (Missouri) | 158.95 mi (255.81 km) |
