| Des Moines to Shoreview (Minnesota) | 243.80 mi (392.36 km) |
| Des Moines to Shorewood (Illinois) | 279.01 mi (449.03 km) |
| Des Moines to Shorewood (Wisconsin) | 310.56 mi (499.79 km) |
| Des Moines to Short Hills (New Jersey) | 1,002.69 mi (1,613.67 km) |
| Des Moines to Short Pump (Virginia) | 891.56 mi (1,434.83 km) |
| Des Moines to Show Low (Arizona) | 1,025.37 mi (1,650.18 km) |
| Des Moines to Shreveport (Louisiana) | 629.33 mi (1,012.81 km) |
| Des Moines to Sicklerville (New Jersey) | 981.99 mi (1,580.36 km) |
| Des Moines to Sidney (Ohio) | 500.61 mi (805.65 km) |
| Des Moines to Sierra Madre (California) | 1,421.75 mi (2,288.09 km) |
| Des Moines to Sierra Vista (Arizona) | 1,153.10 mi (1,855.73 km) |
| Des Moines to Sierra Vista Southeast (Arizona) | 1,153.81 mi (1,856.88 km) |
| Des Moines to Signal Hill (California) | 1,439.79 mi (2,317.12 km) |
| Des Moines to Sikeston (Missouri) | 388.78 mi (625.68 km) |
| Des Moines to Siloam Springs (Arkansas) | 375.56 mi (604.40 km) |
