| Des Moines to Shelton (Connecticut) | 1,058.06 mi (1,702.78 km) |
| Des Moines to Shelton (Washington) | 1,497.89 mi (2,410.62 km) |
| Des Moines to Shenandoah (Louisiana) | 785.36 mi (1,263.91 km) |
| Des Moines to Shepherdsville (Kentucky) | 487.54 mi (784.61 km) |
| Des Moines to Sheridan (Wyoming) | 707.68 mi (1,138.90 km) |
| Des Moines to Sherman (Texas) | 573.07 mi (922.27 km) |
| Des Moines to Sherrelwood (Colorado) | 608.05 mi (978.56 km) |
| Des Moines to Sherwood (Arkansas) | 470.66 mi (757.45 km) |
| Des Moines to Sherwood (Oregon) | 1,480.60 mi (2,382.79 km) |
| Des Moines to Shiloh (Illinois) | 285.74 mi (459.85 km) |
| Des Moines to Shiloh (Ohio) | 505.80 mi (814.01 km) |
| Des Moines to Shiloh (Pennsylvania) | 885.50 mi (1,425.07 km) |
| Des Moines to Shirley (New York) | 1,077.01 mi (1,733.28 km) |
| Des Moines to Shively (Kentucky) | 474.35 mi (763.40 km) |
| Des Moines to Shoreline (Washington) | 1,465.51 mi (2,358.51 km) |
