| Des Moines to Seymour (Tennessee) | 659.83 mi (1,061.90 km) |
| Des Moines to Shady Hills (Florida) | 1,102.43 mi (1,774.19 km) |
| Des Moines to Shafter (California) | 1,439.78 mi (2,317.11 km) |
| Des Moines to Shaker Heights (Ohio) | 623.43 mi (1,003.31 km) |
| Des Moines to Shakopee (Minnesota) | 221.34 mi (356.21 km) |
| Des Moines to Sharon (Pennsylvania) | 679.21 mi (1,093.09 km) |
| Des Moines to Sharonville (Ohio) | 508.96 mi (819.09 km) |
| Des Moines to Shasta Lake (California) | 1,491.54 mi (2,400.40 km) |
| Des Moines to Shawnee (Kansas) | 187.57 mi (301.87 km) |
| Des Moines to Shawnee (Oklahoma) | 466.36 mi (750.53 km) |
| Des Moines to Sheboygan (Wisconsin) | 334.06 mi (537.62 km) |
| Des Moines to Shelby (North Carolina) | 782.95 mi (1,260.03 km) |
| Des Moines to Shelbyville (Indiana) | 434.35 mi (699.02 km) |
| Des Moines to Shelbyville (Kentucky) | 501.19 mi (806.58 km) |
| Des Moines to Shelbyville (Tennessee) | 570.37 mi (917.93 km) |
