| Des Moines to Security-Widefield (Colorado) | 617.38 mi (993.58 km) |
| Des Moines to Sedalia (Missouri) | 199.06 mi (320.35 km) |
| Des Moines to Sedro-Woolley (Washington) | 1,467.07 mi (2,361.03 km) |
| Des Moines to Seguin (Texas) | 863.09 mi (1,389.01 km) |
| Des Moines to Selden (New York) | 1,067.26 mi (1,717.60 km) |
| Des Moines to Selma (Alabama) | 728.77 mi (1,172.85 km) |
| Des Moines to Selma (California) | 1,431.07 mi (2,303.09 km) |
| Des Moines to Selma (Texas) | 868.91 mi (1,398.37 km) |
| Des Moines to Seminole (Florida) | 1,128.34 mi (1,815.89 km) |
| Des Moines to Seven Hills (Ohio) | 617.58 mi (993.91 km) |
| Des Moines to Seven Oaks (South Carolina) | 854.92 mi (1,375.87 km) |
| Des Moines to Severn (Maryland) | 904.85 mi (1,456.22 km) |
| Des Moines to Severna Park (Maryland) | 912.32 mi (1,468.24 km) |
| Des Moines to Sevierville (Tennessee) | 668.07 mi (1,075.15 km) |
| Des Moines to Seymour (Indiana) | 445.37 mi (716.76 km) |
