| Des Moines to Scottsboro (Alabama) | 630.47 mi (1,014.64 km) |
| Des Moines to Scottsdale (Arizona) | 1,134.49 mi (1,825.78 km) |
| Des Moines to Scranton (Pennsylvania) | 927.21 mi (1,492.20 km) |
| Des Moines to Seabrook (Maryland) | 899.94 mi (1,448.31 km) |
| Des Moines to Seabrook (Texas) | 832.70 mi (1,340.10 km) |
| Des Moines to Seaford (New York) | 1,046.65 mi (1,684.42 km) |
| Des Moines to Seagoville (Texas) | 637.03 mi (1,025.20 km) |
| Des Moines to Seal Beach (California) | 1,436.58 mi (2,311.96 km) |
| Des Moines to Searcy (Arkansas) | 449.01 mi (722.60 km) |
| Des Moines to Seaside (California) | 1,543.43 mi (2,483.92 km) |
| Des Moines to SeaTac (Washington) | 1,461.26 mi (2,351.67 km) |
| Des Moines to Seattle (Washington) | 1,463.67 mi (2,355.56 km) |
| Des Moines to Sebastian (Florida) | 1,207.05 mi (1,942.56 km) |
| Des Moines to Sebring (Florida) | 1,192.05 mi (1,918.43 km) |
| Des Moines to Secaucus (New Jersey) | 1,015.72 mi (1,634.64 km) |
