| Des Moines to Savannah (Georgia) | 950.80 mi (1,530.17 km) |
| Des Moines to Sayreville (New Jersey) | 1,006.23 mi (1,619.37 km) |
| Des Moines to Sayville (New York) | 1,066.76 mi (1,716.78 km) |
| Des Moines to Scaggsville (Maryland) | 895.02 mi (1,440.40 km) |
| Des Moines to Scarsdale (New York) | 1,028.30 mi (1,654.89 km) |
| Des Moines to Schaumburg (Illinois) | 286.36 mi (460.86 km) |
| Des Moines to Schenectady (New York) | 1,008.94 mi (1,623.73 km) |
| Des Moines to Schererville (Indiana) | 318.94 mi (513.28 km) |
| Des Moines to Schertz (Texas) | 869.34 mi (1,399.06 km) |
| Des Moines to Schiller Park (Illinois) | 297.02 mi (478.00 km) |
| Des Moines to Schofield Barracks (Hawaii) | 3,944.45 mi (6,347.98 km) |
| Des Moines to Scotchtown (New York) | 993.40 mi (1,598.72 km) |
| Des Moines to Scottdale (Georgia) | 740.71 mi (1,192.06 km) |
| Des Moines to Scotts Valley (California) | 1,542.62 mi (2,482.61 km) |
| Des Moines to Scottsbluff (Nebraska) | 518.45 mi (834.37 km) |
