| Des Moines to Santa Rosa (California) | 1,547.44 mi (2,490.36 km) |
| Des Moines to Santaquin (Utah) | 956.08 mi (1,538.67 km) |
| Des Moines to Santee (California) | 1,414.15 mi (2,275.85 km) |
| Des Moines to Sapulpa (Oklahoma) | 407.06 mi (655.09 km) |
| Des Moines to Saraland (Alabama) | 801.68 mi (1,290.18 km) |
| Des Moines to Sarasota (Florida) | 1,165.94 mi (1,876.39 km) |
| Des Moines to Sarasota Springs (Florida) | 1,169.82 mi (1,882.65 km) |
| Des Moines to Saratoga (California) | 1,538.28 mi (2,475.62 km) |
| Des Moines to Saratoga Springs (New York) | 1,016.07 mi (1,635.21 km) |
| Des Moines to Saratoga Springs (Utah) | 957.06 mi (1,540.25 km) |
| Des Moines to Sartell (Minnesota) | 281.23 mi (452.60 km) |
| Des Moines to Satellite Beach (Florida) | 1,180.39 mi (1,899.66 km) |
| Des Moines to Sauk Rapids (Minnesota) | 279.47 mi (449.76 km) |
| Des Moines to Sault Ste. Marie (Michigan) | 570.06 mi (917.42 km) |
| Des Moines to Savage (Minnesota) | 220.21 mi (354.39 km) |
