| Des Moines to Sanford (Maine) | 1,167.50 mi (1,878.90 km) |
| Des Moines to Sanford (North Carolina) | 884.57 mi (1,423.58 km) |
| Des Moines to Sanger (California) | 1,424.88 mi (2,293.12 km) |
| Des Moines to Santa Ana (California) | 1,427.68 mi (2,297.63 km) |
| Des Moines to Santa Barbara (California) | 1,497.89 mi (2,410.62 km) |
| Des Moines to Santa Clara (California) | 1,533.00 mi (2,467.13 km) |
| Des Moines to Santa Clara (Oregon) | 1,497.82 mi (2,410.51 km) |
| Des Moines to Santa Clarita (California) | 1,436.21 mi (2,311.36 km) |
| Des Moines to Santa Cruz (California) | 1,545.66 mi (2,487.49 km) |
| Des Moines to Santa Fe (New Mexico) | 781.66 mi (1,257.96 km) |
| Des Moines to Santa Fe (Texas) | 845.93 mi (1,361.39 km) |
| Des Moines to Santa Fe Springs (California) | 1,430.15 mi (2,301.60 km) |
| Des Moines to Santa Maria (California) | 1,519.28 mi (2,445.04 km) |
| Des Moines to Santa Monica (California) | 1,448.20 mi (2,330.65 km) |
| Des Moines to Santa Paula (California) | 1,467.02 mi (2,360.95 km) |
