| Des Moines to San Luis Obispo (California) | 1,521.02 mi (2,447.85 km) |
| Des Moines to San Marcos (California) | 1,413.39 mi (2,274.63 km) |
| Des Moines to San Marcos (Texas) | 843.64 mi (1,357.70 km) |
| Des Moines to San Marino (California) | 1,426.43 mi (2,295.62 km) |
| Des Moines to San Mateo (California) | 1,546.44 mi (2,488.76 km) |
| Des Moines to San Pablo (California) | 1,538.84 mi (2,476.53 km) |
| Des Moines to San Rafael (California) | 1,547.52 mi (2,490.49 km) |
| Des Moines to San Ramon (California) | 1,522.28 mi (2,449.87 km) |
| Des Moines to San Tan Valley (Arizona) | 1,140.28 mi (1,835.10 km) |
| Des Moines to Sand Springs (Oklahoma) | 399.30 mi (642.61 km) |
| Des Moines to Sandusky (Ohio) | 564.08 mi (907.80 km) |
| Des Moines to Sandy (Oregon) | 1,452.79 mi (2,338.03 km) |
| Des Moines to Sandy (Utah) | 950.84 mi (1,530.23 km) |
| Des Moines to Sandy Springs (Georgia) | 729.30 mi (1,173.70 km) |
| Des Moines to Sanford (Florida) | 1,122.36 mi (1,806.26 km) |
