| Des Moines to San Diego (California) | 1,421.79 mi (2,288.14 km) |
| Des Moines to San Diego Country Estates (California) | 1,398.80 mi (2,251.15 km) |
| Des Moines to San Dimas (California) | 1,411.60 mi (2,271.74 km) |
| Des Moines to San Fernando (California) | 1,437.31 mi (2,313.12 km) |
| Des Moines to San Francisco (California) | 1,548.70 mi (2,492.39 km) |
| Des Moines to San Gabriel (California) | 1,426.62 mi (2,295.92 km) |
| Des Moines to San Germán (Puerto Rico) | 2,255.37 mi (3,629.66 km) |
| Des Moines to San Jacinto (California) | 1,381.14 mi (2,222.72 km) |
| Des Moines to San Jose (California) | 1,528.29 mi (2,459.54 km) |
| Des Moines to San Juan (Puerto Rico) | 2,278.98 mi (3,667.66 km) |
| Des Moines to San Juan (Texas) | 1,093.82 mi (1,760.34 km) |
| Des Moines to San Juan Capistrano (California) | 1,424.39 mi (2,292.33 km) |
| Des Moines to San Leandro (California) | 1,535.06 mi (2,470.43 km) |
| Des Moines to San Lorenzo (California) | 1,534.44 mi (2,469.45 km) |
| Des Moines to San Luis (Arizona) | 1,317.08 mi (2,119.63 km) |
