| Des Moines to Salisbury (New York) | 1,042.21 mi (1,677.28 km) |
| Des Moines to Salisbury (North Carolina) | 816.11 mi (1,313.41 km) |
| Des Moines to Salmon Creek (Washington) | 1,472.01 mi (2,368.97 km) |
| Des Moines to Salt Lake City (Utah) | 952.58 mi (1,533.04 km) |
| Des Moines to Sammamish (Washington) | 1,450.43 mi (2,334.25 km) |
| Des Moines to San Angelo (Texas) | 795.69 mi (1,280.54 km) |
| Des Moines to San Anselmo (California) | 1,550.17 mi (2,494.76 km) |
| Des Moines to San Antonio (Texas) | 880.70 mi (1,417.35 km) |
| Des Moines to San Benito (Texas) | 1,091.45 mi (1,756.51 km) |
| Des Moines to San Bernardino (California) | 1,384.65 mi (2,228.38 km) |
| Des Moines to San Bruno (California) | 1,550.93 mi (2,495.98 km) |
| Des Moines to San Buenaventura (California) | 1,477.98 mi (2,378.58 km) |
| Des Moines to San Carlos (California) | 1,545.39 mi (2,487.06 km) |
| Des Moines to San Carlos Park (Florida) | 1,239.78 mi (1,995.24 km) |
| Des Moines to San Clemente (California) | 1,423.95 mi (2,291.62 km) |
