| Des Moines to Saddlebrooke (Arizona) | 1,134.15 mi (1,825.24 km) |
| Des Moines to Safety Harbor (Florida) | 1,121.21 mi (1,804.42 km) |
| Des Moines to Saginaw (Michigan) | 508.09 mi (817.70 km) |
| Des Moines to Saginaw (Texas) | 635.89 mi (1,023.36 km) |
| Des Moines to Sahuarita (Arizona) | 1,165.48 mi (1,875.66 km) |
| Des Moines to Saks (Alabama) | 688.62 mi (1,108.22 km) |
| Des Moines to Salem (Massachusetts) | 1,163.53 mi (1,872.53 km) |
| Des Moines to Salem (Ohio) | 664.02 mi (1,068.64 km) |
| Des Moines to Salem (Oregon) | 1,489.92 mi (2,397.79 km) |
| Des Moines to Salem (Virginia) | 780.57 mi (1,256.20 km) |
| Des Moines to Salem Lakes (Wisconsin) | 288.86 mi (464.87 km) |
| Des Moines to Salida (California) | 1,479.44 mi (2,380.93 km) |
| Des Moines to Salina (Kansas) | 284.53 mi (457.90 km) |
| Des Moines to Salinas (California) | 1,532.06 mi (2,465.61 km) |
| Des Moines to Salisbury (Maryland) | 977.61 mi (1,573.31 km) |
