| Des Moines to Reidsville (North Carolina) | 830.30 mi (1,336.24 km) |
| Des Moines to Reisterstown (Maryland) | 892.86 mi (1,436.92 km) |
| Des Moines to Rendon (Texas) | 652.55 mi (1,050.18 km) |
| Des Moines to Reno (Nevada) | 1,378.98 mi (2,219.25 km) |
| Des Moines to Renton (Washington) | 1,456.52 mi (2,344.05 km) |
| Des Moines to Republic (Missouri) | 306.02 mi (492.50 km) |
| Des Moines to Reston (Virginia) | 875.08 mi (1,408.30 km) |
| Des Moines to Revere (Massachusetts) | 1,158.88 mi (1,865.04 km) |
| Des Moines to Rexburg (Idaho) | 934.27 mi (1,503.56 km) |
| Des Moines to Reynoldsburg (Ohio) | 576.48 mi (927.76 km) |
| Des Moines to Rialto (California) | 1,390.21 mi (2,237.33 km) |
| Des Moines to Richardson (Texas) | 618.08 mi (994.71 km) |
| Des Moines to Richfield (Minnesota) | 228.86 mi (368.32 km) |
| Des Moines to Richfield (Wisconsin) | 297.02 mi (478.01 km) |
| Des Moines to Richland (Washington) | 1,312.48 mi (2,112.24 km) |
